The ORx Platform Technology
ORx Science & Technology
ORx's Platform Technology
Our suite of advanced technologies is aimed enabling and controlling the delivery as well as optimizing bioavailability performance of orally ingestible drugs.
HydroMatrix™ - Hydrostatic Matrix Oral Delivery Technology
HydroMatrix™ is a platform technology for the development orally ingestible controlled release pharmaceutical dosage forms. The essential feature of the technology is the utility of novel hydrostatic couple compositions acting in tandem to induce hydrostatic pressure within a matrix solid dosage form such as a tablet or pellet.
HydroMatrix™ is a novel concept based on the effect of a hydrostatic pressure modulating polymers within the core of the solid dosage form in which differential hydrostatic pressure is created by the interaction between two polymers (hydrostatic couple) produces a release controlling pressure for zero-order release of the active ingredient The understanding and controlling of properties associated with the hydrostatic couple facilitates time-release delivery of a wide range of pharmaceuticals.
The HydroMatrix™ technology accommodates oral control release of a wide range of drugs and beneficial agents whose kinetics are usually difficult to control and deliver due to high drug loading and highly solubility. HydroMatrix technologies are based on the active drug being embedded in a homogeneous mixture of two or more polymers referred as the hydrostatic couple components. HydroMatrix™ based formulations can also be programmed to delay onset of drug release as well as deliver multiple drugs at
different rates simultaneously. This technology is simple to implement, easy to scale-up, inexpensive and offers numerous advantages over other technologies geared towards similar goals.
OraRem™ - Oral Reverse-Micellar Drug Delivery & Targeting Technology)
OraRem™ is a broad-based proprietary bio-enabling drug delivery and drug targeting platform technology, which makes it possible to orally deliver poorly absorbable therapeutic molecule without altering its chemical form or biological integrity. The OraRem™ Technology enhances the absorption of the therapeutic compound as well as improves its target-tissue distribution.
The key benefit of OraRem™ Technology is that it improves the ability of the body to not only enhance but also control the rate and timing of absorption leading to significant and improved bioavailability and drug distribution.
Drug molecules possess many different physiochemical properties, charge densities, shapes or "conformations." Some conformations and charge densities can be transported across cell membranes, while others are too large or too charged to do so. The OraRem® Technology uses the body's natural passive transcellular transport process to enable small to medium sized and highly charged molecules to cross cell membranes through a novel “in-situ” formation of reverse-micelles. Once the drug
molecule crosses the membrane, OraRem delivery agent(s) dissociates from the drug molecule, which then reestablishes its natural conformation and returns to its therapeutically active state.
Through the OraRem™ system, delivery agents or "carriers" facilitate or enable transport of therapeutic molecules across biological membranes such as those of the gastrointestinal tract, and further enable tissue-specific distribution and targeting allowing the therapeutic molecules to exert their desired pharmacological effect. The delivery agents have no known pharmacological activity themselves at the intended clinical dose levels.
Our OraRem™ bio-enabling technology works within the human body, responding to the multivariate external environment of the Gastro-Intestinal Tract (GIT), releasing active drug and delivery agents and concurrently forming a reverse-micellar unit which facilitates transportation and distribution of the drug. This is achieved with:
• Entropic Recognition and Self-assembly to form drug encased reverse micelle
• Passive and facilitated passive diffusion of reverse-micellar micro units
• Defensive Control over adverse factors such as food effects or excess acidity
• Temporal Control over drug distribution and targeting of adipose tissues.
• Spatial Control over the site and timing drug release from ingested dosage form
• Rate Control over the entire release profile to deliver pre-programmed extended
release